Tumour suppressor super models
نویسندگان
چکیده
منابع مشابه
p53 tumour suppressor
Other speculated functions include1⁄4 does it really need more? Well, it seems to function in multicellular development and differentiation, too, and there’s some evidence that it’s an exonuclease. If you’re beginning to think that researchers from all areas of biology are obsessed with p53, witness the number of grant applications claiming that studies of p53 will provide a cure for cancer, ex...
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The tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) plays essential roles in regulating signalling pathways involved in cell growth and apoptosis, and is inactivated in a wide variety of tumours. The role of PTEN as a tumour suppressor has been firmly established; however, the mechanism(s) by which its function and activity are regulated remains elusive. Here,...
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Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in pancreatic neuroendocrine tumour cells is unknown. Pancreatic neuroendocrine cell lines (n = 5) and human tumour tissues (n = 19) were studied for changed p53 coding sequence, transcription, and translation. Proliferative activity of tumour c...
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Maspin is a protein that belongs to serin protease inhibitor (serpin) superfamily. The purpose of this study was to review the literature concerning the expression of maspin in salivary gland tumours. A literature search was done using MEDLINE, accessed via the National Library of Medicine PubMed interface. Statistical analysis was not done because only seven studies were available in literatur...
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Since cancer is one of the leading causes of death worldwide, there is an urgent need to find better treatments. Currently, the use of chemotherapeutics remains the predominant option for cancer therapy. However, one of the major obstacles for successful cancer therapy using these chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. T...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2005
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg1546